Ok so what is Febrile you might ask. Fever (also known as pyrexia or a febrile response) is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is most accurately characterized as a temporary elevation in the body’s thermoregulatory set-point, usually by about 1–2 °C.

It is DIFFERENT FROM HYPERTHERMIA!!! Hyperthermia is an increase in body temperature over the body’s thermoregulatory set-point, due to excessive heat production or insufficient thermoregulation, or both.
In FEVER, the elevation in thermoregulatory set-point means that the previous “normal body temperature” is considered hypothermic, and effector mechanisms kick in - a cold sensation, and an increase in heart rate, muscle tone and shivering – all attempt to counteract the perceived hypothermia, thereby reaching the new thermoregulatory set-point. A fever is one of the body’s mechanisms to try to neutralize the perceived threat inside the body, be it bacterial or viral, by thermal denaturation.

There are arguments for and against the usefulness of fever, and the issue is controversial. Theoretically, fever can aid in host defense. There are certainly some important immunological reactions that are sped up by temperature, and some pathogens with strict temperature preferences could be hindered. Fevers may be useful to some extent since they allow the body to reach high temperatures, causing an unbearable environment for some pathogens. White blood cells also rapidly proliferate due to the suitable environment and can also help fight off the harmful pathogens and microbes that invaded the body.
So what induces fever? Pyrogens. Endogenous (from the inside the body) pyrogens include cytokines such as interleukin 1 or 6 (IL-1 or IL-6) and even tumor necrosis factor (TNF) secrete by the various immune cells. Exogenous (from the outside of the body) pyrogens include bacterial constituents such as lipopolisaccharide (LPS), which causes the release of endogenous factors. Ultimately, these endogenous factors (e.g. IL-1) activate the arachidonic acid pathway to produce Prostaglandin E2 (PGE2) which act on the brain to cause the hypothalamus to effect the febrile response. The brain orchestrates this via the autonomous nervous system. And we dont have control over it. Aww
Or do we?
It can be easily treated by lowering the thermoregulatory set point with the use of anti-pyretics such as paracetamol (panadol), ibuprofen or acetominophen. However, fever should not necessarily be treated. Fever is an important signal that there’s something wrong in the body, and it can be used to govern medical treatment and gauge its effectiveness. Moreover, not all fevers are of infectious origin.

Fever can alternatively be treated facilitating heat loss. Heat removal is generally by wet cloth or pads, usually applied to the forehead, but also through bathing the body in tepid water. This is particularly important for babies, where drugs should be avoided. However, using water that is too cold can induce vasoconstriction, and reduce effective heat loss.
- The Benthic Canine
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